# Evaluation of rs781673405, rs1244378045, rs767450259, rs750556128, rs369143448, rs143353036, and rs759369504 mutations in terms of polymorphism in diabetic obese and non-diabetic obese individuals

## TL;DR

This study evaluates specific gene mutations linked to obesity and diabetes, finding some alleles protect against diabetic obesity while others increase risk.

## Contribution

This is the first study to investigate the protective and risk roles of specific TRAIL gene polymorphisms in diabetic obesity.

## Key findings

- The T-allele of rs767450259 polymorphism protects against diabetic obesity.
- The G-allele of rs369143448 polymorphism has protective effects against diabetic obesity.
- The A-allele of rs750556128 polymorphism increases obesity risk in diabetic patients by 1.3-fold.

## Abstract

Obesity is among the important healthcare issues in which there is an abnormal increase in body fat because energy intake is higher than energy expenditure. The Tumor Necrosis Factor (TNF)-alpha overexpression in adipose tissue plays important roles in mediating obesity and insulin resistance. “TNF-related apoptosis-inducing Ligand (TRAIL(TNSF10))”, which is a member of the TNF family, is expressed as a Type-II Transmembrane Protein with an effect on the development of obesity and diabetes.

The rs781673405, rs1244378045, rs767450259, rs750556128, rs369143448, rs143353036, and rs759369504 polymorphisms of TRAIL, which were determined to play protective roles against diabetes, were evaluated with the RT-qPZR Method in the present study.

It was found that the genotype distribution of TRAIL rs767450259 Polymorphism was significant and the T-Allele had protective effects against diabetic obesity. It was also found that the G-Allele of the rs369143448 Polymorphism had protective roles against diabetic obesity. It was shown that carrying the A-Allele in the rs750556128 Polymorphism might increase the risk of obesity in diabetic patients by 1.3-fold.

The present study makes a significant contribution to the literature data because it is the first to investigate these polymorphisms.