# Capillary leak syndrome following cesarean section in a patient with severe preeclampsia: a case report

**Authors:** Haijuan Jin, Huimin Li, Junjun Cheng, Wenjuan Huang, Da Lin

PMC · DOI: 10.3389/fmed.2025.1540957 · Frontiers in Medicine · 2025-04-29

## TL;DR

A rare case of capillary leak syndrome occurred after a cesarean section in a woman with severe preeclampsia and was successfully treated.

## Contribution

This is the first documented case of capillary leak syndrome following cesarean delivery in a patient with severe preeclampsia.

## Key findings

- CLS developed post-cesarean in a 37-year-old with severe preeclampsia.
- Prompt treatment with albumin, corticosteroids, and fluids improved the condition rapidly.
- Early diagnosis and intervention may improve outcomes in similar cases.

## Abstract

Capillary leak syndrome (CLS) is a rare, often idiopathic condition, typically characterized by edema, hypotension, hypovolemic shock, and hypoalbuminemia. The progression of CLS is rapid, with a complex clinical course. If left undiagnosed or untreated, CLS can cause multiorgan failure and significantly increase the risk of mortality. Although CLS is generally associated with conditions such as infections, trauma, or autoimmune disorders, the occurrence of the condition following a cesarean section in patients with severe preeclampsia is exceedingly uncommon.

A 37-year-old pregnant woman at 37 weeks of gestation underwent a cesarean section due to severe preeclampsia. Postoperatively, the patient developed sudden hypoxemia, massive ascites, oliguria, hypotension, and hypoalbuminemia. Following prompt identification and diagnosis, treatment was initiated with blood pressure management, magnesium sulfate to alleviate spasms, and supplementation with hydroxyethyl starch, albumin, and crystalloids. Additionally, corticosteroids were administered to improve capillary permeability. The condition was rapidly managed, with subsequent follow-up revealing no recurrence of similar issues.

To the best of our knowledge, this is the first documented case of CLS occurring following a cesarean delivery in a patient with severe preeclampsia. The successful management of this patient offers valuable insights into early diagnosis, prompt treatment, and the potential to improve the prognosis of similar cases.

## Linked entities

- **Chemicals:** magnesium sulfate (PubChem CID 24083), hydroxyethyl starch (PubChem CID 16213095)
- **Diseases:** capillary leak syndrome (MONDO:0001956), severe preeclampsia (MONDO:0001641)

## Full-text entities

- **Genes:** ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** trauma (MESH:D014947), hypotension (MESH:D007022), hypoxemia (MESH:D000860), infections (MESH:D007239), spasms (MESH:D013035), oliguria (MESH:D009846), CLS (MESH:D019559), hypoalbuminemia (MESH:D034141), edema (MESH:D004487), ascites (MESH:D001201), autoimmune disorders (MESH:D001327), preeclampsia (MESH:D011225), hypovolemic shock (MESH:D012769), multiorgan failure (MESH:D051437)
- **Chemicals:** hydroxyethyl starch (-), magnesium sulfate (MESH:D008278)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12069035/full.md

## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC12069035/full.md

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Source: https://tomesphere.com/paper/PMC12069035