# Tandem Cu(I)-Catalyzed Dipolar Cycloaddition–C–H Activation for the In-Flow Synthesis of N-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates

## TL;DR

Scientists developed a continuous flow method to efficiently synthesize complex organic molecules using copper-catalyzed reactions.

## Contribution

A new continuous flow synthesis method combining CuAAC and C–H activation is introduced for making triazole derivatives.

## Key findings

- The process uses a packed bed reactor for efficient Cu(I)-catalyzed reactions.
- The method enables environmentally friendly synthesis of functionalized organic molecules.
- The approach combines click chemistry with C–H activation in a single setup.

## Abstract

A telescoped process under continuous flow conditions
is described
for the synthesis of N-pyridyl-5-amino-1,2,3-triazole-4-carboxylate
derivatives catalyzed by copper salts in a packed bed reactor. The
synthetic approach takes first advantage of click chemistry, specifically
relying on Cu(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition
(CuAAC), to achieve the efficient and selective assembly of a triazole
ring, followed by a copper-mediated C–H activation, that substitutes
an inert C–H bond with a C–N bond, providing an environmentally
acceptable and cost-effective strategy for synthesizing highly functionalized
organic molecules.