This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCδ-JNK pathway

Abstract
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Taxonomy
TopicsAldose Reductase and Taurine · Retinoids in leukemia and cellular processes · Arsenic contamination and mitigation
After this article [1] was published, concerns were raised about Figures 2, 4–6, 8, and 10. Specifically, concerns were identified within the figures of [1] as follows:
Additionally, when aspect ratios and/or orientation are adjusted, there appear to be similarities between panels or parts of panels in [1] and in other articles published by the same authors, including:
The first author JD stated that work for different projects was conducted simultaneously in the laboratory and the similarities noted between Figures 2 and 6 and other articles published by the same group were the result of errors made during figure preparation. They stated that the original underlying images and raw data are not available.
In the absence of the original images, the above concerns remain unresolved and the PLOS One Editors retract this article.
It was additionally noted that there appear to be similarities between the ‘Phospho PKCδ’ panel in Figure 8B and the ‘Keap1’ panel of Figure 12 in [6], which was published later by different authors.
The ‘As treated’ panel in Figure 2C reports material from [4], published in February 2010 by Taylor & Francis, and the lower Liver – ‘Phospho ERK1/2’ panel in Figure 6C reports material from [5], published in May 2010 by Elsevier, which are not offered under a CC BY license and are therefore excluded from this article’s [1] license.
JD, PM, and PCS did not agree with the retraction. JG either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Das J, Ghosh J, Manna P, Sil PC. Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PK Cdelta-JNK pathway. P Lo S One. 2010;5(9):e 12602. doi: 10.1371/journal.pone.0012602 20830294 PMC 2935368 · doi ↗ · pubmed ↗
- 2Pal PB, Pal S, Das J, Sil PC. Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes. Amino Acids. 2012;42(5):1669–83. doi: 10.1007/s 00726-011-0869-3 21373768 · doi ↗ · pubmed ↗
- 3Pal S, Pal PB, Das J, Sil PC. Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro. Toxicology. 2011;283(2–3):129–39. doi: 10.1016/j.tox.2011.03.006 21420465 · doi ↗ · pubmed ↗
- 4Das J, Ghosh J, Manna P, Sil PC. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P 450 2E 1. Free Radic Res. 2010;44(3):340–55. doi: 10.3109/10715760903513017 20166895 · doi ↗ · pubmed ↗
- 5Ghosh J, Das J, Manna P, Sil PC. Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway. Food Chemistry. 2010;123(4):1062–75. doi: 10.1016/j.foodchem.2010.05.062 · doi ↗
- 6Miltonprabu S, Muthumani M. Dimethoxycurcumin potentially protects arsenic induced oxidative hepatic injury, inflammation and apoptosis via Nrf 2-Keap 1 signaling in rats. Biomed Prev Nut. 2014;4(4):561–77. doi: 10.1016/j.bionut.2014.08.003 · doi ↗
