# CyberKnife Versus Four-Dimensional Computed Tomography-Guided Stereotactic Body Radiation Therapy in the Treatment of Lung Cancer: A Case Report

**Authors:** Lingrong Tang, Lei Yao, Guang Li

PMC · DOI: 10.7759/cureus.82138 · Cureus · 2025-04-12

## TL;DR

This case report compares CyberKnife and 4DCT-guided SBRT for lung cancer treatment, highlighting their respective advantages in targeting tumors and protecting healthy tissue.

## Contribution

The paper provides a comparative analysis of CyberKnife and 4DCT-SBRT through a real-world case, emphasizing clinical advantages in specific scenarios.

## Key findings

- CyberKnife demonstrated advantages in target delineation and dose distribution for one lesion.
- 4DCT-SBRT showed effectiveness in treating another lesion while preserving normal tissue.
- The case highlights the suitability of each technique depending on lesion characteristics.

## Abstract

Stereotactic body radiation therapy (SBRT) has emerged as a critical therapeutic option for treating lung and other solid tumors. Two prominent high-precision SBRT techniques currently in use are four-dimensional computed tomography-guided linear accelerator-based SBRT (4DCT-SBRT) and CyberKnife. This case presents a patient diagnosed with two distinct pulmonary lesions, each treated separately using 4DCT-SBRT and CyberKnife. By comparing target delineation, dose distribution, lesion response, and the capability to spare normal tissues, we evaluate the specific advantages of CyberKnife for particular clinical scenarios.

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138)

## Full-text entities

- **Diseases:** tumors (MESH:D009369), Lung Cancer (MESH:D008175), lung and (MESH:D008171)
- **Chemicals:** CyberKnife (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12068358/full.md

## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12068358/full.md

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Source: https://tomesphere.com/paper/PMC12068358