# Single Session of Calcium Hydroxylapatite, Incobotulinumtoxin A, and Hyaluronic Acid for Gluteal Aesthetic Improvement

**Authors:** David Di Sessa, Carla de Sanctis Pecora, Rossana Cantanhede Farias de Vasconcelos, Gustavo Limongi Moreira

PMC · DOI: 10.1111/jocd.70227 · Journal of Cosmetic Dermatology · 2025-05-12

## TL;DR

A single treatment combining three substances improved buttock appearance, with high patient satisfaction over 90 days.

## Contribution

This study evaluates a novel single-session combination treatment for gluteal aesthetics using three products.

## Key findings

- Flaccidity improved in 9 out of 10 patients after 90 days.
- Cellulite improved in 4 out of 10 patients in static assessments and 9 out of 10 in dynamic assessments.
- 100% of patients and 60% of physicians reported significant aesthetic improvement after 90 days.

## Abstract

While various techniques exist to treat the buttocks, few combine multiple products in a single session, offering both aesthetic and logistical benefits.

To evaluate the aesthetic improvement of the buttocks in patients treated with a combination of calcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC), Incobotulinumtoxin A (IncoBoNT‐A), and cohesive poly‐densified matrix hyaluronic acid (CPM‐HA V) in one session.

This retrospective observational study involved women aged from 35 to 55 years who underwent the combined technique. Data were collected from the patient's charts, and photos were taken before treatment, and at 30 and 90 days post‐procedure. Two independent physicians evaluated cellulite (5‐point scale) and flaccidity (4‐point scale) in all patients. Aesthetic improvements were assessed by patients and physicians using the GAIS (5‐point) scale.

Ten women aged 45.3 (±5.2) years participated. Initially, 80% presented moderate to severe flaccidity, and 30% and 90% presented moderate to very severe cellulite in relaxed and contracted buttocks, respectively. After 90 days, flaccidity improved in 9/10 patients, and cellulite in 4/10 and 9/10 patients in static and dynamic assessments, respectively. There was a moderate correlation between the assessments at baseline and after 90 days. The aesthetic appearance of the buttocks was rated as much improved or very much improved by 100% of the patients and 60% of the physicians after 90 days.

A single‐session combined application of CaHA‐CMC, IncoBoNT‐A, and CPM‐HA effectively improved flaccidity and cellulite, resulting in high patient satisfaction.

## Linked entities

- **Chemicals:** calcium hydroxylapatite (PubChem CID 14781), carboxymethylcellulose (PubChem CID 24748)

## Full-text entities

- **Diseases:** cellulite (MESH:D000071697), flaccidity (MESH:D009123)
- **Chemicals:** Hyaluronic Acid (MESH:D006820), Calcium Hydroxylapatite (MESH:D017886), CPM-HA V (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12067859/full.md

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Source: https://tomesphere.com/paper/PMC12067859