# A comparison of diffusion tensor imaging tractography approaches to identify the Frontal Aslant Tract in neurosurgical patients

## TL;DR

This study compares different imaging methods to identify a brain pathway called the Frontal Aslant Tract and finds the best approach for mapping it.

## Contribution

The study introduces a comparison of ROI-based tractography approaches to delineate the Frontal Aslant Tract using diffusion tensor imaging.

## Key findings

- Using the SFG ROI with an endpoint in IFG pars opercularis yields the highest streamline counts and fiber volumes for FAT.
- FAT shows left dominance in all subjects, regardless of gender.
- Older patients (over 55) have higher Mean Diffusivity and lower Fractional Anisotropy in FAT compared to younger patients.

## Abstract

This study aims to present various tractography methods for delineating the Frontal Aslant Tract (FAT) and to quantify morphological features of FAT based on diffusion tensor imaging.

The study includes 68 patients, for which FAT was reconstructed using the Region Of Interest (ROI)-based approach. The ROIs were defined in either SFG – Superior Frontal Gyrus (ROI 1), or SMA—Supplementary Motor Area (ROI 2). The respective endpoints were located in the Inferior Frontal Gyrus (IFG)—either in pars opercularis or in pars triangularis. For each patient, FAT was delineated using four combinations of the above ROI–endpoint pairs.

The highest streamline counts and fiber volumes of FAT were obtained using ROI 1 (i.e., SFG) with the endpoint in IFG pars opercularis. All subjects expressed left dominance of the pathway quantified by the higher streamline counts and fiber volumes regardless of gender. Additionally, higher Mean Diffusivity (MD) and lower Fractional Anisotropy (FA) values were observed in patients above 55 years of age than in younger patients.

FAT is a neural pathway that can be tracked based on various anatomical landmarks. Clinically, it appears that delineating FAT between SFG and the pars opercularis region of IFG is optimal, as it is directly associated with the highest number of fibers and the greatest volume of the tract contained between these points.