# Calcifying fibrous tumor of stomach: a rare case report of an upper gastrointestinal bleeding

**Authors:** BaoLong Ye, ZiWen Chen, JunFeng Xie, KeXing Xi, Xin Zeng, CaiLiang Zhong

PMC · DOI: 10.3389/fonc.2025.1512964 · Frontiers in Oncology · 2025-04-28

## TL;DR

A rare case of a calcifying fibrous tumor in the stomach causing upper gastrointestinal bleeding is reported, highlighting the importance of considering this diagnosis in similar clinical presentations.

## Contribution

This case report adds to the limited literature on gastric calcifying fibrous tumors and emphasizes their potential to mimic more common gastrointestinal tumors.

## Key findings

- A 39-year-old male presented with upper gastrointestinal bleeding due to a gastric calcifying fibrous tumor.
- The tumor was initially misdiagnosed as a gastrointestinal stromal tumor but was confirmed histopathologically as a CFT.
- CFTs are rare and can present with active bleeding, requiring surgical intervention.

## Abstract

Calcifying fibrous tumor (CFT) is an uncommon benign fibrous neoplastic lesion that may manifest as singular or multiple tumors and usually occurs in children or young adults. CFT originates in the muscularis propria of the stomach and is a very rare disease. Here, we report a case of gastric CFT with upper gastrointestinal bleeding.

A 39-year-old male was urgently referred to our hospital with haematemesis and melena that had developed over the course of 2 hours. Enhanced abdominal CT imaging revealed a nodular lesion, measuring approximately 3.2 × 2.1 × 1.6 cm, protruding from the posterior wall of the gastric body into the gastric lumen. The lesion exhibited scattered calcifications, smooth margins, and a CT attenuation value of 50 Hounsfield units (HU). Gastroscopic ultrasonography performed in the gastroenterology department revealed a semicircular submucosal mass with signs of active bleeding. Initially, the tumor was diagnosed as a gastrointestinal stromal tumor (GIST), and surgical intervention was undertaken due to ongoing hemorrhage. Postoperative histopathological examination confirmed the diagnosis of a gastric calcifying fibrous tumor (CFT).

CFT originating from the muscularis propria of the stomach is exceptionally rare, and the case presented here mimicked a gastric submucosal tumor (SMTs),clinicians should consider this differentia diagnosis when evaluating patients with suspected cases.

## Linked entities

- **Diseases:** gastrointestinal stromal tumor (MONDO:0011719)

## Full-text entities

- **Diseases:** bleeding (MESH:D006470), upper gastrointestinal bleeding (MESH:D006471), GIST (MESH:D046152), melena (MESH:D008551), calcifications (MESH:D002114), Calcifying fibrous tumor of stomach (MESH:D013274), CFT (MESH:C537961), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12066241/full.md

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Source: https://tomesphere.com/paper/PMC12066241