# Primary Cardiac Myxofibrosarcoma: A Case Report

## TL;DR

A rare case of primary cardiac myxofibrosarcoma is reported, highlighting its aggressive nature and diagnostic challenges.

## Contribution

This paper presents a unique clinical case of a rare cardiac tumor with unusual recurrence and progression.

## Key findings

- The tumor recurred twice after initial resection and later metastasized to the pleura.
- Histological and immunohistochemical analysis confirmed the diagnosis of myxofibrosarcoma.
- Chemotherapy with doxorubicin was ineffective due to severe side effects and tumor progression.

## Abstract

Primary cardiac tumors are rare, with malignant myxofibrosarcoma cases being particularly uncommon, while cardiac myxoma is a common diagnosis in clinical practice. We present a case of cardiac myxofibrosarcoma, whose clinical course was quite unusual.

A 67-year-old woman with no prior history of cardiac tumors was admitted for dyspnea and was found to have a 60 mm tumor in the left atrium. Despite initial resection, the tumor recurred twice, and a subsequent pleural mass biopsy revealed metastasis of myxofibrosarcoma. Retrospective analysis confirmed that the pathological findings of all the resected tumors were consistent with myxofibrosarcoma. Chemotherapy with doxorubicin was initiated, but severe side effects led to its discontinuation. The tumors continued to grow, causing significant pain, and she passed away a year later.

The differential diagnosis of cardiac myxofibrosarcoma is challenging due to its similarity to benign myxomas. Accurate diagnosis requires thorough histological and immunohistochemical evaluation is essential.