# A Rare Case of Primary Hyperaldosteronism Resulting in Severe Hypokalemia

**Authors:** Saad Sameer, Aya J Qassim, Ali Aqel, Yousef H Al-Asa'd, Shaefiq Babu Thappy

PMC · DOI: 10.7759/cureus.82069 · Cureus · 2025-04-11

## TL;DR

A 43-year-old woman with severe hypokalemia was diagnosed with primary hyperaldosteronism and successfully treated with surgery.

## Contribution

This case report highlights a rare presentation of primary hyperaldosteronism with severe hypokalemia and emphasizes the importance of timely diagnosis and multidisciplinary care.

## Key findings

- The patient presented with severe hypokalemia and prolonged QT interval, leading to a diagnosis of primary hyperaldosteronism.
- Urgent adrenalectomy was curative and improved the patient's condition significantly.

## Abstract

Hyperaldosteronism often clinically manifests as hypertension with mild to moderate hypokalemia. However, in rare cases, it can also present primarily with severe hypokalemia. In this case report, we will be discussing our patient, a 43-year-old woman who presented with abdominal cramps and vomiting, along with severe muscle cramps resulting in an inability to walk. She was found to have an undetectable level of serum potassium and prolonged QT interval on her ECG. After aggressive electrolyte correction and further imaging and endocrinology studies, she was diagnosed to have primary hyperaldosteronism. She was appropriately referred for urgent outpatient adrenalectomy, which turned out to be curative. Our case highlights the importance of timely diagnosis, interventions, and multidisciplinary care for patients with primary hyperaldosteronism.

## Linked entities

- **Diseases:** primary hyperaldosteronism (MONDO:0001422), hypokalemia (MONDO:0003019)

## Full-text entities

- **Diseases:** muscle cramps (MESH:D009120), hypertension (MESH:D006973), Hypokalemia (MESH:D007008), prolonged QT interval (MESH:D008133), abdominal cramps (MESH:D003085), vomiting (MESH:D014839), Hyperaldosteronism (MESH:D006929)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12066027/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12066027/full.md

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Source: https://tomesphere.com/paper/PMC12066027