# Bilateral Optic Disc Edema as the Presenting Sign of Brain Metastasis in Ovarian Carcinoma: A Case Report

**Authors:** Alka Tripathi, Nivedita Singh, Richa Agarwal, Neha Singh, Amit Thangjam

PMC · DOI: 10.7759/cureus.82049 · Cureus · 2025-04-10

## TL;DR

A rare case of ovarian cancer relapse presented as bilateral optic disc swelling due to brain metastasis, highlighting the need for thorough evaluation of ophthalmic symptoms in cancer patients.

## Contribution

This case report highlights the rare occurrence of brain metastasis from ovarian carcinoma presenting with bilateral papilledema.

## Key findings

- Bilateral papilledema was the earliest clinical sign of brain metastasis in a patient with a history of ovarian carcinoma.
- Brain metastasis from ovarian cancer is rare but can occur within one year of initial treatment.
- Ophthalmic symptoms should prompt detailed neurological evaluation in cancer survivors.

## Abstract

Brain metastases are one of the common causes of brain tumours in adults and lead to increased morbidity and mortality in cancer patients. Primary cancers such as lung, breast, and melanoma are most likely to metastasize to the brain; however, the incidence of brain metastases in ovarian cancer is low. Papilledema due to brain metastasis occurs when the tumor mass within the brain leads to increased intracranial pressure (ICP). We present an unusual case of bilateral papilledema as the earliest clinical manifestation of brain metastasis in a 48-year-old woman who had undergone treatment for ovarian carcinoma one year ago. We are trying to highlight the rare relapse of ovarian carcinoma (OC) in the form of brain metastasis within one year of therapy and presenting with ophthalmic complaints. Therefore, we emphasize detailed history taking, clinical examination, and neuroimaging of any patient so that early diagnosis and treatment can be done.

## Linked entities

- **Diseases:** ovarian carcinoma (MONDO:0005140)

## Full-text entities

- **Diseases:** lung, breast, and melanoma (MESH:D061325), OC (MESH:D010051), Brain metastases (MESH:D001932), Brain Metastasis (MESH:D009362), Primary cancers (MESH:D009369), Optic Disc Edema (MESH:D010211)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12065931/full.md

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Source: https://tomesphere.com/paper/PMC12065931