# Gastrointestinal Stromal Tumors in the Stomach With Tumor Growth and Hemorrhage During Conservative Management: A Report of Two Cases

**Authors:** Masaya Iwamuro, Satoru Kikuchi, Shinji Kuroda, Takehiro Tanaka, Motoyuki Otsuka

PMC · DOI: 10.7759/cureus.82046 · Cureus · 2025-04-10

## TL;DR

This paper reports two cases of stomach tumors that grew and bled during non-surgical treatment, showing the risks of conservative management in patients with other health issues.

## Contribution

The novelty lies in highlighting tumor progression and bleeding risks in conservatively managed GIST patients through real-world case reports.

## Key findings

- Two gastric GIST cases were managed conservatively due to comorbidities.
- Both tumors grew and caused gastrointestinal bleeding during conservative management.
- The cases emphasize the potential risks of non-surgical treatment for GISTs.

## Abstract

Gastrointestinal stromal tumors (GISTs) are often detected incidentally during esophagogastroduodenoscopy. Although surgical resection is the standard treatment for GISTs, patients with significant comorbidities may not be eligible for surgery and are managed conservatively. Herein, we report two cases of gastric GISTs that were initially observed during the management of other comorbidities but subsequently became enlarged, resulting in gastrointestinal bleeding. These cases highlight the potential risks of tumor progression and bleeding in patients undergoing conservative management.

## Linked entities

- **Diseases:** gastrointestinal stromal tumors (MONDO:0011719)

## Full-text entities

- **Diseases:** Hemorrhage (MESH:D006470), GISTs (MESH:D046152), gastrointestinal bleeding (MESH:D006471), Tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12065673/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12065673/full.md

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Source: https://tomesphere.com/paper/PMC12065673