# Development of a Machine Learning Algorithm for the Prediction of WHO Grade 1 Meningioma Recurrence

## TL;DR

This study develops a machine learning model to predict recurrence of WHO grade 1 meningiomas after surgery, using factors like age and histopathology.

## Contribution

A new machine learning algorithm, Risk-SLIM, is introduced to predict meningioma recurrence beyond traditional classification methods.

## Key findings

- The MRS model identified age, female gender, and Ki-67/MIB-1 index as significant predictors of recurrence.
- The model outperformed univariate analysis in identifying multiple risk factors for meningioma recurrence.
- Machine learning can improve recurrence prediction even after gross total resection.

## Abstract

Objective

Meningiomas commonly recur following gross total resection (GTR), and the risk of recurrence is difficult to predict using current classification schemes such as the World Health Organization (WHO) tumor grade. This study aimed to create a predictive model of recurrence risk following GTR of WHO grade 1 meningiomas based on histopathological and epidemiological factors.

Methods

A retrospective chart review was completed for all patients at our institution who underwent their first surgery for a WHO grade 1 meningioma between 2017 and 2022. Those with genetic predispositions, such as neurofibromatosis type 2, were excluded. Baseline characteristics, including histopathology findings, were obtained, and we used a Risk-calibrated Superspase Linear Integer Model (Risk-SLIM) with a five-fold cross-validation (CV) to create a predictive model of recurrence over an average follow-up of three years.

Results

Univariate analysis of our selected variables revealed a significant predictive association between WHO grade 1 meningioma recurrence and subtotal resection but not with any other variable. However, the meningioma recurrence score (MRS) generated by our machine learning algorithm revealed multiple predictive factors of recurrence, including age, female gender, and various histopathologic features, including the Ki-67/MIB-1 index.

Conclusions

Machine learning algorithms like the one we present here may help identify patients at high risk of recurrence of their WHO grade 1 meningioma, and they are more likely to benefit from closer postoperative surveillance or adjuvant treatment, even when GTR is achieved.