This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: Methylation‐Mediated miR‐214 Regulates Proliferation and Drug Sensitivity of Renal Cell Carcinoma Cells Through Targeting LIVIN
TL;DR
This retracted paper claimed that miR-214 affects kidney cancer cell growth and drug response by targeting LIVIN, but issues like image duplication and missing ethics approval invalidated the findings.
Contribution
The paper originally proposed a novel regulatory mechanism involving miR-214 and LIVIN in renal cell carcinoma.
Findings
miR-214 was reported to regulate cancer cell proliferation and drug sensitivity.
Methylation was suggested to influence miR-214 expression in kidney cancer cells.
LIVIN was identified as a target of miR-214 in this context.
Abstract
RETRACTION: H. Xu, S. Wu, X. Shen, Z. Shi, D. Wu, Y. Yuan, W. Jiang, Q. Wang, Q. Ke, Q. Mao, X. Li, Y. Liu, P. Yuan, Q. Zhang, E. Huang, and X. Chen, “Methylation‐Mediated miR‐214 Regulates Proliferation and Drug Sensitivity of Renal Cell Carcinoma Cells Through Targeting LIVIN,” Journal of Cellular and Molecular Medicine 24, no. 11 (2020): 6410–6425, https://doi.org/10.1111/jcmm.15287. The above article, published online on 12 May 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Stefan Constantinescu; The Foundation for Cellular and Molecular Medicine; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplication and resizing within the article (Figure 4C, 5B and 6B) and between this (Figure 4B)…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsEpigenetics and DNA Methylation · Renal cell carcinoma treatment · Renal and related cancers
RETRACTION: H. Xu, S. Wu, X. Shen, Z. Shi, D. Wu, Y. Yuan, W. Jiang, Q. Wang, Q. Ke, Q. Mao, X. Li, Y. Liu, P. Yuan, Q. Zhang, E. Huang, and X. Chen, “Methylation‐Mediated miR‐214 Regulates Proliferation and Drug Sensitivity of Renal Cell Carcinoma Cells Through Targeting LIVIN,” Journal of Cellular and Molecular Medicine 24, no. 11 (2020): 6410–6425, https://doi.org/10.1111/jcmm.15287.
The above article, published online on 12 May 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Stefan Constantinescu; The Foundation for Cellular and Molecular Medicine; and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate image duplication and resizing within the article (Figure 4C, 5B and 6B) and between this (Figure 4B) and another article published elsewhere by a different group of authors in a different scientific context. The investigation also revealed missing ethical approval regarding the animal experiments presented in the article. Thus, the editors have lost confidence in the presented data and consider the conclusions of this manuscript substantially compromised. The authors and their institute were informed of the concerns and the decision to retract but they remained unresponsive.