Macular thickness and vascular density assessment using optical coherence tomography and optical coherence tomography angiography imaging in iron ore mine personnel

TL;DR

This study used OCT and OCTA imaging to assess retinal changes in iron ore mine workers but found no significant differences compared to a control group.

Contribution

The study is the first to investigate retinal structural and vascular changes in iron ore mine workers using OCT and OCTA.

Findings

No significant difference in foveal thickness between mine workers and controls.

Vessel density in retinal capillary plexus showed no significant variation between groups.

Occupational exposure in iron ore mines was not associated with retinal structural changes.

Abstract

To assess macular anatomical and vascular parameters in individuals working in iron ore mines using Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) imaging to explore potential correlations between this occupational exposure and retinal changes.

Individuals from the Sangan iron ore mine in Iran were included in a comparative cross-sectional observational study. An age-matched normal control group was selected from healthy participants employed at Mashhad University of Medical Sciences. Following thorough medical evaluations, participants underwent OCT and OCTA imaging. The macular thickness profile, vessel density (VD) of the superficial (SCP) and deep retinal capillary plexus (DCP), and the area of the foveal avascular zone (FAZ) were measured in our cases and compared with age-matched normal controls.

One hundred and one individuals, with an average age of 38.3 ± 5.59 years in the case group and 38.5 ± 5.59 years in the control group, were enrolled in the study. The difference in mean foveal thickness between cases (50.75 ± 9.13) and normal controls (50.38 ± 8.29) was not statistically significant (p = 0.758). Similarly, the mean VD in SCP and DCP for the case group (49.08 ± 2.20 and 49.32 ± 2.42, respectively) and the control group (49.45 ± 3.54 and 49.36 ± 3.97) did not show significant differences. Additionally, there were no significant changes (p-value > 0.05) in macular thickness and VD in other retinal regions when comparing the case and control groups.

The research did not establish a significant association between occupational exposure in an iron ore mine and retinal structural changes or alterations in macular VD.

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