# Clinical and Electrophysiological Characterization of Diabetic Neuropathy in a Sub‐Saharan African Cohort

## TL;DR

This study finds a high prevalence of diabetic neuropathy in Cameroon, including subtypes not previously reported in sub-Saharan Africa.

## Contribution

The study is the first in sub-Saharan Africa to use objective electrophysiological measures to identify novel diabetic neuropathy subtypes.

## Key findings

- Diabetic sensorimotor polyneuropathy was the most common subtype at 63.8%.
- Small fiber neuropathy and treatment-induced diabetes neuropathy were newly identified in sub-Saharan Africa.
- The overall prevalence of diabetic neuropathy was 86.9%, higher than prior African studies.

## Abstract

Diabetic neuropathy (DN) is the most frequent complication of diabetes mellitus, contributing to increased morbidity and mortality. Previous clinical studies on DN in sub‐Saharan Africa (sSA) have used purely clinical approaches, potentially underestimating the true magnitude of this disease. This study was designed to determine the prevalence of definite diabetic neuropathy and describe the different subtypes using objective small and large fiber function measures.

This was a hospital‐based cross‐sectional study that included diabetes and prediabetes patients, followed up at Jordan Medical Services, Yaoundé, Cameroon, between March 2022 and February 2023. The “Toronto Clinical Neuropathy Score” and “Douleur Neuropathique en 4” questionnaires were used for clinical evaluation. Autonomic symptoms were equally recorded. Nerve conduction studies and Sudoscan were used for electrophysiological assessments of large and small fibre functions.

Eighty‐four participants were included; 91.7% had type 2 DM, 2.4% had type 1 DM, and 6% had glucose intolerance. DN was found in 73/84 (86.9%). Diabetic sensorimotor polyneuropathy (DSP) was the most frequent subtype (63.8%), followed by diabetic autonomic neuropathy (40.5%), mononeuropathy (36.9%), asymmetric axonal sensory neuropathy (4.8%) and treatment‐induced neuropathy of diabetes (TIND) in 1.2% of patients. The prevalence of large and small fibre neuropathies was 38.1% and 25.0%, respectively.

The prevalence of DN and specifically DSP in our study was higher than previously described in African literature. We identified subtypes never before reported in sSA, mainly small fibre neuropathy and TIND. This may have management and policy implications.