Ovarian Metastatic Recurrence of Cervical Squamous Cell Carcinoma: A Case Report

TL;DR

A rare case of cervical cancer recurring as ovarian metastases after initial treatment is reported, highlighting unusual tumor behavior.

Contribution

This is the first documented case of ovarian metastases from cervical cancer following irradiation.

Findings

Ovarian metastases were discovered two years after complete remission from cervical cancer.

Histopathological and immunohistochemical analysis confirmed the metastasis origin.

The case raises questions about tumor biology and resistance to irradiation.

Abstract

Ovarian metastases from squamous cell carcinoma of the uterine cervix are extremely rare. We present the case of a 57-year-old patient who was followed for stage IVA cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO), initially treated with concurrent chemoradiation. Two years after complete remission, she developed bilateral ovarian metastases, which were incidentally discovered and confirmed by histopathological and immunohistochemical analysis. This case represents the first description of ovarian metastases following irradiation of a locally advanced cervical cancer. The occurrence of ovarian metastases in this context, where the ovaries had been irradiated, raises questions about tumor biology and treatment resistance.

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