Research advances in traditional Chinese medicine formulae and active components targeting lipid metabolism for hepatocellular carcinoma therapy
Yang Liu, Jie Yang, Fenghua Yu, Li Li, Ning Zhao, Cheng Lu, Aiping Lu, Xiaojuan He
TL;DR
This paper explores how traditional Chinese medicine can target lipid metabolism to treat hepatocellular carcinoma, a deadly liver cancer.
Contribution
It reviews recent advances in TCM formulae and components that regulate lipid metabolism in hepatocellular carcinoma.
Findings
Abnormal lipid metabolism plays a key role in hepatocellular carcinoma progression.
Traditional Chinese medicine formulae and active components can regulate lipid metabolism in HCC.
Understanding these relationships may improve targeted HCC therapies.
Abstract
Hepatocellular carcinoma (HCC) has a relatively poor prognosis and a high degree of malignancy. However, the therapeutic drugs are limited. In recent years, abnormal lipid metabolism and its important role in HCC has been reported, and emerging studies found that some formulae and active components of traditional Chinese medicine (TCM) can regulate abnormal lipid metabolism in HCC, showing their good application prospects. Therefore, this article summarizes the changes and the roles of lipid metabolites in HCC progression, and discusses the role of formulae and active components of TCM for the treatment of HCC based on their regulation on abnormal lipid metabolism. A deeper understanding of their relationship may help the precise use of these formulae and active components in HCC.
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Taxonomy
TopicsCancer, Lipids, and Metabolism · Peroxisome Proliferator-Activated Receptors · Lipid metabolism and biosynthesis