Mapping the global research landscape on psoriasis and the gut microbiota: visualization and bibliometric analysis

TL;DR

This paper maps global research on psoriasis and gut microbiota, showing a rapid growth in studies and identifying key authors, countries, and research trends.

Contribution

The study provides a comprehensive bibliometric analysis and visualization of psoriasis and gut microbiota research from 2004 to 2024.

Findings

Research on psoriasis and gut microbiota grew slowly from 2004–2014 but rapidly from 2014–2024.

China produced the most publications, while the U.S. had the highest citations per article.

Recent studies focus on mechanisms like gut barrier disruption and Th17 cell activation in psoriasis.

Abstract

Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis. Recently, the role of gut microbiota in psoriasis has attracted increasing attention. A systematic bibliometric analysis of relevant literature is necessary to understand better the current state and development trends in this field.

The Web of Science Core Collection database was searched for literature indexed from 2004 to October 15, 2024. Bibliometric analysis was conducted using Bibliometrix, CiteSpace (version 6.3.R1), R 4.2.2 with the Bibliometrix package, Scimago Graphica 1.0.45, and VOSviewer (version 1.6.20.0) to visualize publication types, years, authors, countries, institutions, journal sources, references, and keywords.

The development of psoriasis and gut microbiota research can be divided into two phases: slow growth (2004–2014) and rapid development (2014–2024). Lidia Rudnicka is the most active and influential author. China produced the highest number of publications, followed by the United States, which had the highest number of citations per article. The International Journal of Molecular Sciences published the most articles. In contrast, articles in the Journal of Investigative Dermatology, British Journal of Dermatology, and Journal of Allergy and Clinical Immunology were cited over 1,000 times. Keyword and co-citation analyses identified evolving research hotspots. Early studies focused on the association between gut microbiota and comorbid inflammatory diseases. Recent research has delved into specific mechanisms, such as disruption of gut barrier function, short-chain fatty acid metabolism alterations, impaired regulatory T-cell function, and excessive activation of Th17 cells. These mechanisms highlight how gut dysbiosis exacerbates psoriasis patients’ systemic inflammation and skin lesions.

The field of psoriasis and gut microbiota research is developing rapidly despite uneven research distribution. This bibliometric evaluation assesses the current state of research and provides new perspectives for understanding the complex interactions between microbes and the host. Future efforts should strengthen international collaboration to deeply explore the mechanisms of gut microbiota’s role in psoriasis, especially its potential applications in disease diagnosis and treatment.

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