Diabetes alters cardiorespiratory dynamics: insights from short-term recurrence quantification analysis of pulse-respiration quotient

TL;DR

This study shows that diabetes affects how the heart and lungs work together, making their interaction less flexible.

Contribution

The study introduces short-term recurrence quantification analysis of PRQ to detect subtle cardiorespiratory dysautonomia in T2DM.

Findings

T2DM participants showed higher recurrence rates and prolonged recurrence time in PRQ during paced breathing.

RQA metrics were more effective than linear indices in distinguishing T2DM from controls.

Entropy-based mutual information revealed distinct compensatory patterns in T2DM during specific tasks.

Abstract

The Pulse-Respiration Quotient (PRQ) is considered a powerful tool for assessing dynamic interactions between cardiac and respiratory rhythms. Type 2 diabetes mellitus (T2DM) disrupts autonomic control, potentially compromising the complexity and adaptability of cardiorespiratory dynamics. In this cross-sectional, exploratory study, we investigated whether T2DM alters cardiorespiratory dynamics by analyzing short-term PRQ signals using conventional linear indices and Recurrence Quantification Analysis (RQA).

Thirty-eight participants (20 T2DM and 18 controls) completed four standardized tasks—supine rest, orthostatic challenge, paced breathing, and the Valsalva maneuver—while electrocardiographic and respiratory signals were continuously recorded. From these signals, R-to-R peak interval (RRI) and breath-to-breath (BB) time series were derived, allowing us to compute the PRQ time series as the ratio of instantaneous heart rate to instantaneous breathing rate. Linear indices of PRQ and RQA metrics were then calculated for the PRQ signals, enabling comparisons between groups (T2DM vs. control) and across tasks. Additionally, entropy-based mutual information (MI) between RRI and BB was assessed as a quantitative measure of cardiorespiratory coupling.

T2DM participants exhibited higher recurrence rates and prolonged recurrence time of the first type in the PRQ series, especially during paced breathing, suggesting a more rigid and less adaptive control mechanism. Although linear PRQ indices showed changes in some stage-dependent responses, they were less adept than RQA metrics at discerning subtle differences between groups. Furthermore, the complementary cardiorespiratory coupling assessment by MI revealed distinct compensatory patterns in T2DM during paced respiration and Valsalva.

These findings indicate potential dysautonomia or partial autonomic dysregulation in individuals with T2DM, as reflected by altered cardiorespiratory dynamics and reduced adaptability.

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