# Electrolyte abnormalities and clinical outcomes in children aged one month to 13 years hospitalized with acute gastroenteritis in two large referral hospitals in Botswana

## TL;DR

This study examines how electrolyte imbalances in children with acute gastroenteritis in Botswana affect hospital stays and mortality.

## Contribution

The study identifies specific electrolyte abnormalities and risk factors for mortality in children with acute gastroenteritis in Botswana.

## Key findings

- 37% of hospitalized children with acute gastroenteritis had electrolyte abnormalities.
- Malnutrition, hypokalaemia, and hypernatraemia were strong predictors of mortality.
- Children with hypokalaemia or hyponatraemia had longer hospital stays.

## Abstract

Acute gastroenteritis (AGE) is a common childhood disease, with a median of 2.5 diarrhoea episodes per child per year in both low- and middle-income countries. Morbidity and mortality from AGE result from a number of causes, including electrolyte abnormalities. This study characterized children hospitalized for AGE in Botswana with and without electrolyte abnormalities. This was a prospective observational study of children under the age of 13 years who were admitted with AGE in Princess Marina Hospital (PMH) and Nyangabgwe Referral Hospital (NRH) between May 2011 and April 2013. All children with serum electrolyte values obtained within 48 hours of admission were included. Patient characteristics and prevalence of electrolyte abnormalities were described. Risk factors for mortality were explored using univariate and multivariate logistic regression analyses. Among 544 patients, 37% had electrolyte abnormalities, namely hyponatraemia (9%), hypernatraemia (12%) and hypokalaemia (16%). Patients with hypernatraemia were younger (median age 6 months) compared to those with normal electrolytes (median age 9 months, p < 0.001). Patients with hypokalaemia presented after a longer duration of diarrhoea (median 4 days) compared to those with normal electrolytes (median 2 days, p < 0.001). Length of stay was longer in hypokalaemic (5 days) and hyponatraemic (5 days) patients compared to patients with hypernatraemia (3 days) and those without electrolyte abnormalities (3 days, p < 0.002). Those with malnutrition were significantly more likely to have electrolyte imbalances, with 19% having hypokalaemia. In multivariate analysis, the strongest predictors of mortality were malnutrition (OR 4.3; 95% CI 1.44-12.9); hypokalaemia (OR 5.5; 95% CI 1.84-16.6) and hypernatraemia (OR 3.9; 95% CI 1.11-13.5). Given the global impact of paediatric AGE, it is important that clinicians take additional care and precautions when admitting children with AGE and hypokalaemia, hypernatraemia, or malnutrition, as these increase the length of stay and odds of mortality.