# Whole-genome sequencing of the first Candida auris clinical isolate from a patient with sepsis in Palestine

**Authors:** Rasmi Abu-Helu, Faiza Tebbji, Ahmad Al Bishawi, Hanaa Baniodeh, Antony T. Vincent, Adnane Sellam

PMC · DOI: 10.1128/mra.01239-24 · Microbiology Resource Announcements · 2025-03-31

## TL;DR

Scientists sequenced a drug-resistant yeast from a sepsis patient in Palestine and found genetic markers linked to resistance.

## Contribution

The study provides the first whole-genome sequence of Candida auris from Palestine and identifies resistance-related SNPs.

## Key findings

- The isolate C. auris Pal1 belongs to geographical Clade I.
- Two SNPs (Erg11Y132F and Mrr1T647N) are associated with azole resistance.

## Abstract

An isolate of the multidrug-resistant yeast Candida auris (Pal1) was identified in the urine of a patient with sepsis and sequenced using both Oxford Nanopore and Illumina sequencing technologies. Phylogenetic analysis placed C. auris Pal1 in the geographical Clade I, with distinct SNPs linked to azole resistance (Erg11Y132F and Mrr1T647N).

## Linked entities

- **Genes:** ERG11 (sterol 14-demethylase) [NCBI Gene 856398], MRR1 (Mrr1p) [NCBI Gene 3641741]

## Full-text entities

- **Diseases:** sepsis (MESH:D018805)
- **Species:** Candidozyma auris (species) [taxon 498019], Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932]
- **Mutations:** T647N

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12060701/full.md

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Source: https://tomesphere.com/paper/PMC12060701