# Whole-genome sequence of Bacillus subtilis TP111, a potential fish probiotic that prevents motile Aeromonas septicemia in Nile tilapia (Oreochromis niloticus)

**Authors:** Sulav Indra Paul, Ashikur Rahman, Md. Javed Foysal, Md. Mahbubur Rahman

PMC · DOI: 10.1128/mra.01350-24 · Microbiology Resource Announcements · 2025-04-21

## TL;DR

This paper presents the whole-genome sequence of Bacillus subtilis TP111, a fish probiotic that may help prevent a deadly disease in Nile tilapia.

## Contribution

The study provides the complete genome sequence of a probiotic strain effective against motile Aeromonas septicemia in fish.

## Key findings

- The genome of Bacillus subtilis TP111 is 4,174,638 bp with 43.48% GC content.
- TP111 has 4,224 potential coding sequences and 10 predicted secondary metabolite gene clusters.
- The strain was isolated from the gut of a healthy Nile tilapia in Bangladesh.

## Abstract

We report the genome of fish probiotic Bacillus subtilis TP111 strain isolated from the gut of a healthy Nile tilapia (Oreochromis niloticus) in Bangladesh. TP111 has a genome size of 4,174,638 bp, 43.48% guanine-cytosine, 243.0× genome coverage with 4,224 potential coding sequences, and 10 predicted secondary metabolite biosynthetic gene clusters.

## Linked entities

- **Species:** Bacillus subtilis (taxon 1423), Oreochromis niloticus (taxon 8128)

## Full-text entities

- **Diseases:** Aeromonas septicemia (MESH:D018805)
- **Chemicals:** guanine (MESH:D006147), cytosine (MESH:D003596)
- **Species:** Oreochromis niloticus (Nile tilapia, species) [taxon 8128]

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12060691/full.md

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Source: https://tomesphere.com/paper/PMC12060691