# Variability in recurrent retroperitoneal liposarcomas: A case series exploring histological subtypes

## TL;DR

This case series examines how different types of retroperitoneal liposarcomas affect patient outcomes and recurrence risks.

## Contribution

The study provides insights into the clinical behavior of distinct histological subtypes of retroperitoneal liposarcomas through a case series.

## Key findings

- Well-differentiated liposarcomas had better outcomes compared to dedifferentiated ones.
- Dedifferentiated liposarcomas required extensive surgery and had higher recurrence risks.
- Recurrence occurred even after complete tumor resection, highlighting the need for long-term monitoring.

## Abstract

Retroperitoneal liposarcomas (RPLPS) are rare soft tissue sarcomas that often present asymptomatically, leading to delayed diagnosis and challenging management. This case series highlights the impact of histological subtypes on prognosis and recurrence.

Three male patients with recurrent RPLPS were compared. Two cases of well-differentiated liposarcoma (WDLPS) had favorable outcomes with tumor-free margins, despite recurrence in one. The third case, a dedifferentiated liposarcoma (DDLPS), presented with a larger, high-grade tumor requiring extensive resection and had a higher recurrence risk.

Histological subtype, tumor size, and grade were key prognostic factors. WDLPS showed better outcomes, while DDLPS was more aggressive despite radical surgery. Recurrence remained a major concern, emphasizing the need for early detection and vigilant long-term surveillance.

This case series underscores the variability in RPLPS presentation and outcomes, highlighting the need for individualized surgical strategies and close follow-up to improve long-term prognosis.

•WDLPS show better outcomes; DDLPS needs aggressive surgery and has higher recurrence risk.•Recurrence occured despite full resection, stressing need for long-term surveillance.•Larger, high-grade tumors like the 57×47×22 cm DDLPS case required multi-organ resection.

WDLPS show better outcomes; DDLPS needs aggressive surgery and has higher recurrence risk.

Recurrence occured despite full resection, stressing need for long-term surveillance.

Larger, high-grade tumors like the 57×47×22 cm DDLPS case required multi-organ resection.