# Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial

## TL;DR

This study compared the effectiveness of human treated dentin matrix and MTA in treating young permanent molars, finding both to be equally successful.

## Contribution

The study introduces human treated dentin matrix as a promising alternative to MTA for apexogenesis in immature teeth.

## Key findings

- Both hTDM and MTA showed 100% clinical success over 18 months.
- Tomographic changes were significant within groups but not between hTDM and MTA.
- hTDM is a viable option for pulp therapy in immature permanent molars.

## Abstract

The concept of vital pulp therapy (VPT) of immature permanent teeth has evolved in recent years. There has been a great tendency towards investigating new pulp capping materials for perfect imitation for natural dentin-pulp complex formation process and restoring the normal tissue’s characteristics. Therefore, this study aimed to assess the clinical and tomographic outcomes of apexogenesis with human treated dentin matrix (hTDM) compared to mineral trioxide aggregate (MTA).

40 bilateral deep carious young mandibular first permanent molars (FPMs) in 20 healthy children aged between 6 and 8 years old were randomly allocated into 2 groups in which the FPMs treated with hTDM and MTA after pulpotomy procedure. The children were followed up clinically at 3, 6, 12, and 18 months. Tomographic evaluation was performed at baseline and 18-month evaluation period.

The overall clinical success rate was 100% in both groups. Regarding tomographic evaluation, the mean differences in root length, periapical diameter and area were statistically significant in each individual group but without statistically significant differences between both groups.

Human TDM hydrogel could be considered a promising pulpotomy agent for immature permanent teeth.

The current clinical trial was recorded at clinicaltrials.gov, NCT06116695, 27/10/2023, Retrospectively registered.