# Possible Capecitabine-Induced Coronary Vasospasm and Myocardial Infarction

## TL;DR

A 77-year-old breast cancer patient developed heart attack symptoms due to capecitabine, a chemotherapy drug, which was resolved after stopping the drug.

## Contribution

Reports a rare case of capecitabine-induced coronary vasospasm and myocardial infarction.

## Key findings

- Patient showed acute myocardial infarction symptoms during capecitabine treatment.
- Coronary angiography showed normal arteries, suggesting vasospasm as the cause.
- Symptoms resolved after discontinuing capecitabine.

## Abstract

Capecitabine is a 5-fluorouracil precursor, approved for breast and colorectal cancer. We report a case of capecitabine-induced coronary vasospasm. A 77-year-old woman with breast cancer receiving capecitabine presented with chest pain, and an electrocardiogram demonstrated acute anterior-lateral myocardial infarction. Coronary angiography demonstrated normal coronary arteries. Discontinuation of capecitabine resolved symptoms. Failing to identify the cardiotoxicity associated with capecitabine could have had serious consequences.