# Novel insights into the association between organ damage and inflammatory response in preoperative abdominal aortic aneurysms

## TL;DR

This study explores how inflammation and organ damage are linked in patients with abdominal aortic aneurysms, suggesting a connection with kidney injury.

## Contribution

The study identifies a novel association between inflammatory markers and kidney function indicators in AAA patients.

## Key findings

- Inflammatory markers were significantly higher in AAA patients compared to controls.
- A weak positive correlation was found between inflammatory index and blood urea nitrogen and creatinine levels.
- The inflammatory state in AAA patients is associated with organ damage, particularly kidney injury.

## Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening condition in the elderly population. The insidious nature of AAA onset makes early detection difficult. Currently, there are few studies on changes in laboratory parameters during AAA development.

This study included 55 elderly patients with AAA who were admitted to the Department of Vascular Medicine, Shougang Hospital, Peking University 2021–2022. Propensity score matching (PSM) in a 1:1 ratio was performed to match the 55 patients and 1,031 controls. In this population of AAA, correlation and regression analyses were used to explore the association between the level of inflammation and each laboratory parameter.

Compared to the control group, significant differences in inflammatory markers, transaminase and bilirubin levels, blood urea nitrogen (BUN) and creatinine (Cr) levels, and ankle-brachial index were found in the aneurysm group. After PSM, the differences between the two groups for each parameter remained statistically significant. Correlation and regression analyses showed a weak positive correlation between the inflammatory index and the BUN and Cr levels (correlation coefficient = 0.22).

Our study demonstrates the presence of a highly inflammatory state and damage to various organs in patients with AAA. This hyperinflammatory state may be associated with kidney injury and is a cause of concern.