# Total intravenous anaesthesia with remimazolam in a patient with progressive supranuclear palsy

**Authors:** T. Oshida, T. Taniguchi

PMC · DOI: 10.1002/anr3.70011 · Anaesthesia Reports · 2025-05-07

## TL;DR

A patient with progressive supranuclear palsy successfully underwent surgery using remimazolam and remifentanil for anesthesia.

## Contribution

This case report introduces remimazolam as a potentially suitable anesthetic for patients with progressive supranuclear palsy.

## Key findings

- Remimazolam combined with remifentanil provided stable anesthesia for a patient with progressive supranuclear palsy.
- The cardiovascular stability and rapid reversibility of remimazolam make it a viable option for such patients.

## Abstract

Progressive supranuclear palsy is a neurodegenerative disease of unknown aetiology; few reports address its anaesthetic management. Remimazolam, a recently approved short‐acting benzodiazepine, was used in combination with remifentanil for total intravenous anaesthesia during open cholecystectomy in a patient with progressive supranuclear palsy. Due to its cardiovascular stable profile and rapid reversibility with flumazenil, remimazolam may serve as a viable option for general anaesthesia in patients with this condition.

## Linked entities

- **Chemicals:** remimazolam (PubChem CID 9867812), remifentanil (PubChem CID 60815), flumazenil (PubChem CID 3373)
- **Diseases:** progressive supranuclear palsy (MONDO:0019037)

## Full-text entities

- **Diseases:** Progressive supranuclear palsy (MESH:D013494), neurodegenerative disease (MESH:D019636)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12058351/full.md

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Source: https://tomesphere.com/paper/PMC12058351