# Abnormal lineage differentiation of peri‐implantation aneuploid embryos revealed by single‐cell RNA sequencing

**Authors:** Xueyao Chen, Hanwen Yu, Yu Yin, Bing Cai, Gaohui shi, Yan Xu, Lujuan Rong, Xiu Yu, Boyan Wang, Canquan Zhou, Jichang Wang, Chenhui Ding, Tianqing Li, Yanwen Xu

PMC · DOI: 10.1002/ctm2.70326 · 2025-05-07

## Full-text entities

- **Genes:** KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, Psg16 (pregnancy specific beta-1-glycoprotein 16) [NCBI Gene 26436] {aka Cea11, PSG, bCEA}, GAN (gigaxonin) [NCBI Gene 8139] {aka GAN1, GIG, KLHL16}, CREBBP (CREB binding lysine acetyltransferase) [NCBI Gene 1387] {aka CBP, KAT3A, MKHK1, RSTS, RSTS1}, ELF3 (E74 like ETS transcription factor 3) [NCBI Gene 1999] {aka EPR-1, ERT, ESE-1, ESX}, Chga (chromogranin A) [NCBI Gene 12652] {aka ChrA, cgA}, CEBPB (CCAAT enhancer binding protein beta) [NCBI Gene 1051] {aka C/EBP-beta, IL6DBP, NF-IL6, TCF5}, CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}, Tbx3 (T-box 3) [NCBI Gene 21386] {aka D5Ertd189e}, CEBPA (CCAAT enhancer binding protein alpha) [NCBI Gene 1050] {aka C/EBP-alpha, CEBP}, HTC2 (hypertrichosis 2 (generalized, congenital)) [NCBI Gene 3342] {aka CGH, CXINSq27.1, HCG}, Itga1 (integrin alpha 1) [NCBI Gene 109700] {aka CD49A, E130012M19Rik, Vla1}, EP300 (EP300 lysine acetyltransferase) [NCBI Gene 2033] {aka KAT3B, MKHK2, RSTS2, p300}, PSG1 (pregnancy specific beta-1-glycoprotein 1) [NCBI Gene 5669] {aka B1G1, CD66f, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1}, stb (stubby) [NCBI Gene 20854], Nr2f2 (nuclear receptor subfamily 2, group F, member 2) [NCBI Gene 11819] {aka 2700033K02Rik, 9430015G03Rik, ARP-1, Aporp1, COUP-TF2, COUP-TFII}, PDGFRA (platelet derived growth factor receptor alpha) [NCBI Gene 5156] {aka CD140A, PDGFR-2, PDGFR2}, Cdx2 (caudal type homeobox 2) [NCBI Gene 12591] {aka Cdx-2}, Dlx6 (distal-less homeobox 6) [NCBI Gene 13396], GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, Sdc1 (syndecan 1) [NCBI Gene 20969] {aka CD138, Sstn, Synd, Synd1, syn-1}, APOBR (apolipoprotein B receptor) [NCBI Gene 55911] {aka APOB100R, APOB48R}, GATA6 (GATA binding protein 6) [NCBI Gene 2627], Prdm5 (PR domain containing 5) [NCBI Gene 70779] {aka 4432417F03Rik, 6530401I24Rik, E130112L17Rik, PFM2}, TEAD4 (TEA domain transcription factor 4) [NCBI Gene 7004] {aka EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1}, KAT8 (lysine acetyltransferase 8) [NCBI Gene 84148] {aka LIGOWS, MOF, MYST1, ZC2HC8, hMOF}, Pcyt1b (phosphate cytidylyltransferase 1, choline, beta isoform) [NCBI Gene 236899] {aka CTTbeta}, POU5F1 (POU class 5 homeobox 1) [NCBI Gene 5460] {aka OCT3, OCT4, OCT4Borf1, OTF-3, OTF3, OTF4}, Creb1 (cAMP responsive element binding protein 1) [NCBI Gene 12912] {aka 2310001E10Rik, 3526402H21Rik, Creb, Creb-1}, FOXO1 (forkhead box O1) [NCBI Gene 2308] {aka FKH1, FKHR, FOXO1A}, TSC1 (TSC complex subunit 1) [NCBI Gene 7248] {aka LAM, TSC}, Chgb (chromogranin B) [NCBI Gene 12653] {aka Scg-1, cgB, sgI}, NANOG (Nanog homeobox) [NCBI Gene 79923], Sox4 (SRY (sex determining region Y)-box 4) [NCBI Gene 20677] {aka Sox-4}
- **Diseases:** TSCs (MESH:D014328), infection (MESH:D007239), aneuploidy (MESH:D000782), embryonic defects (MESH:D018236), T16 (MESH:C538041), M16 (MESH:D009006), PGT (MESH:D013736), implantation failure (MESH:D051437), pregnancy loss (MESH:D000022), monogenic disorders (MESH:D009358)
- **Chemicals:** DAPI (MESH:C007293), A485 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** 8C — Homo sapiens (Human), Melanoma, Cancer cell line (CVCL_VV73)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12056499/full.md

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Source: https://tomesphere.com/paper/PMC12056499