# A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and Radiation Therapy

## TL;DR

A rare bladder cancer case showed significant tumor reduction after using a combination of chemotherapy and radiation therapy.

## Contribution

The case demonstrates the potential effectiveness of etoposide-carboplatin and radiotherapy in treating SCCB.

## Key findings

- Emergency radiotherapy controlled bleeding in a patient with SCCB.
- Etoposide-carboplatin chemotherapy led to significant tumor shrinkage.
- Combination therapy was effective in a case resistant to prior treatments.

## Abstract

Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.

A 62‐year‐old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine‐carboplatin (GEM‐CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide‐carboplatin chemotherapy resulted in significant tumor shrinkage.

This case highlights the potential effectiveness of etoposide‐carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.