# Double Trouble: Leishmaniasis and Cytomegalovirus Colitis in an Immunocompromised Host

**Authors:** Saleh Alghaythi, Aymen Almuhaidb, Badr Al-Bawardy

PMC · DOI: 10.14309/crj.0000000000001687 · ACG Case Reports Journal · 2025-05-05

## TL;DR

A 73-year-old immunocompromised man had rare co-occurrence of leishmaniasis and cytomegalovirus colitis after a kidney transplant.

## Contribution

This case report highlights the unusual coexistence of two rare infections in an immunocompromised patient.

## Key findings

- A gastric ulcer with fungal organisms was found in a post-transplant patient.
- Histopathology revealed cytomegalovirus colitis with superimposed leishmaniasis.
- The patient's immunocompromised state likely contributed to the rare infections.

## Abstract

Leishmaniasis is endemic in several areas of the world. It is a chronic protozoan disease transmitted through the bite of the Phlebotomus fly. Unusual localizations of visceral leishmaniasis are extremely rare and are described in immunocompromised patients. We present a case of a 73-year-old man, postliving nonrelated kidney transplant who complained of melena, fatigue, and weight loss. Gastroscopy showed a large ulcer at the lesser curvature of the stomach, and biopsies demonstrated severe ulceration with superimposed fungal organisms. Colonoscopy showed a polyp in the transverse colon, and histopathological examination revealed cytomegalovirus colitis with superimposed leishmaniasis.

## Linked entities

- **Diseases:** leishmaniasis (MONDO:0011989)
- **Species:** Leishmania (taxon 5658), Cytomegalovirus (taxon 10358)

## Full-text entities

- **Diseases:** polyp (MESH:D011127), protozoan disease (MESH:D011528), weight loss (MESH:D015431), ulcer (MESH:D014456), fatigue (MESH:D005221), visceral leishmaniasis (MESH:D007898), Leishmaniasis (MESH:D007896), melena (MESH:D008551), Cytomegalovirus Colitis (MESH:D003586)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12055041/full.md

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Source: https://tomesphere.com/paper/PMC12055041