Identification of a specific set of genes predicting obesity before phenotype appearance
Céline Jousse, Laurent Parry, Gwendal Cueff, Marion Brandolini-Bunlon, Jérémy Tournayre, Alain Bruhat, Anne-Catherine Maurin, Cyrielle Vituret, Julien Averous, Yuki Muranishi, Pierre Fafournoux
TL;DR
This study identifies a set of genes that can predict obesity risk in mice before symptoms appear, with potential applications in humans.
Contribution
The study discovers a gene expression profile that predicts obesity predisposition across species and sexes before phenotypic signs emerge.
Findings
A set of genes in white adipose tissue correlates with obesity susceptibility before symptoms appear.
The gene expression profile is predictive across species, sexes, and different adipose tissue deposits.
The prediction model was validated using both mouse and human datasets.
Abstract
Obesity poses significant health and socioeconomic challenges, necessitating early detection of predisposition for effective personalized prevention. To identify candidate predictive markers, our study used two mouse models: one exhibiting interindividual variability in obesity predisposition and another inducing metabolic phenotypes through maternal nutritional stresses. In both cases, predisposition was assessed by challenging mice with a high-fat diet. Using multivariate analyses of transcriptomic data from white adipose tissue, we identified a set of genes whose expression correlates with an elevated susceptibility to obesity. Importantly, the expression of these genes was impacted prior to the appearance of any symptoms. A prediction model, incorporating both mouse and publicly available human datasets, confirmed the discriminative capacities of our set of genes across species,…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsAdipose Tissue and Metabolism · Adipokines, Inflammation, and Metabolic Diseases · Regulation of Appetite and Obesity