Epidemiology, Survival, and Second Primary Malignancies in T‐Cell Large Granular Lymphocytic Leukemia

TL;DR

This study explores the epidemiology, survival rates, and risk of second cancers in patients with T-cell large granular lymphocytic leukemia.

Contribution

The study identifies an increased risk of secondary primary malignancies in T-LGL patients compared to the general population.

Findings

Patients with T-LGL have a higher incidence of secondary primary malignancies.

Hematological malignancies are more common within the first 10 years after diagnosis.

Solid tumors are more prevalent after 10 years following T-LGL diagnosis.

Abstract

Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T‐LGL.

The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T‐LGL diagnosed between 2000 and 2019, and patients with primary T‐LGL were analyzed.

Patients with primary T‐LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T‐LGL diagnosis.

Patients with primary T‐LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk.

The authors have confirmed clinical trial registration is not needed for this submission

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