Predictive Factors for the Discontinuation of Renal Replacement Therapy in Critically Ill Adults: A Systematic Review and Meta-Analysis
Eman Nasr Taha, Alaa H Ewida, Nehal N Elsheshtawi, Shimaa A Ragab, Dina Alaraby, Rasha Ewida, Ahmed Elmalky, Mohamad-Hani Temsah, Sidharth K Sethi, Rupesh Raina, Khalid Alhasan
TL;DR
This study identifies factors that predict when renal replacement therapy can be safely stopped in critically ill adults with acute kidney injury.
Contribution
The study provides a meta-analysis of predictive factors for discontinuing continuous renal replacement therapy in ICU patients.
Findings
CRRT duration, urine output, creatinine clearance, and NGAL are predictive of successful weaning from CRRT.
Evidence is limited on optimal thresholds for urine output and serum creatinine for weaning decisions.
The relationship between predictive factors and CRRT weaning remains poorly understood.
Abstract
Acute kidney injury (AKI) is a decline in kidney function. Acute kidney injury frequently occurs as a complication among patients who are hospitalized or critically ill. Consequently, we aimed to examine the factors that could predict the cessation of renal replacement therapy (RRT) in individuals with severe AKI. We conducted a systematic review and meta-analysis with a comprehensive literature search in PubMed, Excerpta Medica database (Embase), and the Cochrane Library to identify relevant studies exploring factors associated with a successful transition from continuous renal replacement therapy (CRRT). The search was conducted from each database from beginning until December 1, 2022. The research was carried out on adult critically ill patients taking RRT while being supported in an intensive care unit (ICU) environment.We identified a total of 11 studies through our search. The…
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Taxonomy
TopicsAcute Kidney Injury Research · Dialysis and Renal Disease Management · Muscle and Compartmental Disorders