# Editorial: Unveiling inflammaging – mechanistic insights on aging and related diseases

**Authors:** Senthil Kumaran Satyanarayanan, Barani Kumar Rajendran

PMC · DOI: 10.3389/fmed.2025.1607050 · 2025-04-22

## Full-text entities

- **Genes:** TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, GHR (growth hormone receptor) [NCBI Gene 2690] {aka GHBP, GHIP}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, KL (klotho) [NCBI Gene 9365] {aka HFTC3, KLA}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, TLR3 (toll like receptor 3) [NCBI Gene 7098] {aka CD283, IIAE2, IMD83}, POSTN (periostin) [NCBI Gene 10631] {aka OSF-2, OSF2, PDLPOSTN, PN}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, EFEMP1 (EGF-like fibulin extracellular matrix protein 1) [NCBI Gene 2202] {aka ARCL1D, DHRD, DRAD, FBLN3, FBNL, FIBL-3}, TLR7 (toll like receptor 7) [NCBI Gene 51284] {aka IMD74, SLEB17, TLR7-like}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}
- **Diseases:** ligament ossification (MESH:D017887), DN (MESH:D003928), SDDs (MESH:D019636), metabolic decline (MESH:D008659), MetS (MESH:D024821), immune dysregulation (OMIM:614878), renal disease (MESH:D007674), neuroinflammation (MESH:D000090862), Inflammatory (MESH:D007249), musculoskeletal disorders (MESH:D009140), renal (MESH:D006030), infection (MESH:D007239), intervertebral disc degeneration (MESH:D055959), Alzheimer's and Parkinson's disease (MESH:D010300), post-COVID (MESH:D000094024), KOA (MESH:D020370), Aging (MESH:D019588)
- **Chemicals:** ROS (-)
- **Species:** Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Homo sapiens (human, species) [taxon 9606]

---
Source: https://tomesphere.com/paper/PMC12052547