Causal link between mental disorders and gastrointestinal diseases: a Mendelian randomization study

TL;DR

This study uses genetic data to explore if mental disorders cause gastrointestinal diseases, finding a possible link between Parkinson’s disease and gastric cancer.

Contribution

The study provides a causal analysis using Mendelian randomization to assess the relationship between mental disorders and gastrointestinal diseases.

Findings

Parkinson’s disease shows a potential causal link to gastric cancer (OR = 0.929, p = 0.029).

Other mental disorders like depression and schizophrenia do not show a causal link to gastrointestinal diseases.

Robustness analysis confirmed the consistency of the findings for Parkinson’s disease and gastric cancer.

Abstract

Observational research suggests that mental diseases may increase the risk of gastrointestinal diseases. However, the causal link between these conditions remains unclear. In this study, we conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal associations between common mental diseases and the risk of gastrointestinal diseases.

First, a series of parameters were set to select single-nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS). Second, A two-sample Mendelian randomization analysis was conducted to investigate the causal link between mental diseases (Alzheimer’s disease, depression, major depressive disorder, Parkinson’s disease, schizophrenia) and gastrointestinal diseases (gastritis and duodenitis, gastric cancer) while removing outliers using MR-PRESSO. Finally, eight methods of MR analysis were used to generate forest plots, including inverse variance weighted (IVW), inverse variance weighted (fixed effects) (IVW fixed effects), maximum likelihood (ML), MR-Egger, weighted median, penalized weighted median, simple mode, and weighted mode, with IVW considered the primary method.

The result demonstrated that most MDs have no evidence of a causal link between gastrointestinal diseases except Parkinson’s disease and gastric cancer based on the IVW method (OR = 0.929 [95% CI = 0.869–0.992], p = 0.029). Subsequently, we performed a robustness analysis to ensure consistency.

Our method provided evidence supporting a causal link between Parkinson’s disease and the risk of gastric cancer. However, no evidence was found for other mental diseases influencing the risk of gastrointestinal diseases. Further research is warranted to explore how mental diseases affect the development of gastrointestinal diseases.

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