# Chitosan-supported CuI-catalyzed cascade reaction of 2-halobenzoic acids and amidines for the synthesis of quinazolinones

## TL;DR

A new catalyst made from chitosan and copper helps efficiently create quinazolinones from specific acids and amidines under mild conditions.

## Contribution

A chitosan-supported CuI catalyst enables efficient quinazolinone synthesis with high yields and broad substrate scope.

## Key findings

- The CS@CuI catalyst achieves up to 99% yield in quinazolinone synthesis.
- The reaction works under mild conditions with a broad range of substrates (30 examples).

## Abstract

A chitosan-supported CuI (CS@CuI) catalyst was developed for the synthesis of quinazolinones from 2-halobenzoic acids (including iodine and bromine) and amidines. The reaction proceeds under mild reaction conditions, demonstrating a broad substrate scope (30 examples) and good catalytic efficiency (up to 99% yield).