# Hemophagocytic Syndrome: A Serious Complication in Non-Hodgkin Lymphoma

**Authors:** Samantha González Delgado, Rebeca Deyanira González García, Luis Paulo Ugarte Peláez, Diana Laura Morales Wong, Itzel Araceli Ortiz Meza

PMC · DOI: 10.7759/cureus.81705 · 2025-04-04

## TL;DR

This paper discusses hemophagocytic syndrome, a rare but serious condition in adults, and emphasizes the need for early diagnosis to improve patient outcomes.

## Contribution

The paper highlights the importance of considering HPS in the differential diagnosis of persistent inflammatory conditions in adults.

## Key findings

- Hemophagocytic syndrome is rare in adults but can have an aggressive clinical course.
- Prompt recognition of HPS may lead to better patient outcomes.
- Severe infections and hematologic malignancies are primary causes of HPS in adults.

## Abstract

Hemophagocytic syndrome (HPS) is a common complication in pediatric populations but a rare disease in adults. Also known as hemophagocytic lymphohistiocytosis (HLH), the few cases reported in adults have been primarily caused by severe infections and hematologic malignancies. We highlight the importance of considering HPS as a differential diagnosis in patients with persistent inflammatory conditions. This report describes the aggressive clinical course of a 58-year-old female patient. Prompt recognition of HPS may improve outcomes in such cases.

## Linked entities

- **Diseases:** Hemophagocytic syndrome (MONDO:0015540), Non-Hodgkin Lymphoma (MONDO:0018908)

## Full-text entities

- **Diseases:** HLH (MESH:D051359), hematologic malignancies (MESH:D019337), infections (MESH:D007239), inflammatory conditions (MESH:D007249), Non-Hodgkin Lymphoma (MESH:D008228)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12050044/full.md

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Source: https://tomesphere.com/paper/PMC12050044