# Insidious Primary Mediastinal Large B-Cell Lymphoma in a Young Female: A Case Report and Literature Review

## TL;DR

A rare case of aggressive B-cell lymphoma in a young woman presented with heart-related symptoms instead of typical signs.

## Contribution

Highlights an atypical presentation of PMBCL involving the left ventricle without traditional compressive symptoms.

## Key findings

- PMBCL was diagnosed in a young female presenting with palpitations and tachycardia.
- The tumor was a 16-cm infiltrative mass localized in the left ventricle.
- No cardiopulmonary compressive symptoms like SVC syndrome were present.

## Abstract

Primary mediastinal large B-cell lymphoma (PMBCL) is a highly aggressive malignancy primarily observed in female patients during their third decade of life. This rare condition, with an incidence of 0.4 per million, traditionally presents with B symptoms or compressive-based sequela such as SVC syndrome or respiratory distress. In this report, we present the case of a young female who presented for palpitations and tachycardia without cardiopulmonary compressive–based symptoms diagnosed with a large 16-cm infiltrative PMBCL localized in the left ventricle.