# Common Variable Immunodeficiency Revealed by Bronchiectasis: A Case Report

## TL;DR

A 38-year-old woman with a history of tuberculosis and bronchiectasis was diagnosed with common variable immunodeficiency, a condition affecting immunoglobulin production and causing recurrent infections.

## Contribution

This case report highlights bronchiectasis as a key manifestation of CVID and emphasizes the importance of immunoglobulin replacement therapy.

## Key findings

- CVID was diagnosed after ruling out malignancies and finding reduced immunoglobulin levels.
- Bronchiectasis was identified as a significant pulmonary manifestation in this patient.
- Immunoglobulin replacement therapy is essential for long-term management of CVID.

## Abstract

We report a case of a 38-year-old female with a past medical history of lymph node tuberculosis treated for six months in 2015, history of bronchiectasis from the past six years, and recurrent sinopulmonary infections, who was subsequently diagnosed to have common variable immunodeficiency (CVID). She had reduced levels of immunoglobulins during our diagnostic workup, after ruling out hematological malignancy and solid tumors. CVID is a highly heterogeneous group of disorders characterized by a primary defect in immunoglobulin production and an inability to mount a specific humoral response against exogenous antigens. The most frequently reported pulmonary manifestations of CVID are infectious pneumonias. Bronchiectasis, resulting from recurrent infections, is the third most common pulmonary manifestation observed in CVID patients, following pneumonia and bacterial bronchitis. The therapeutic management of CVID focuses on evaluating complications, with particular emphasis on the risks of bronchial dystrophy (bronchiectasis) and bronchial colonization by antibiotic-resistant pathogens. Respiratory physiotherapy is a key element in the management of bronchial suppuration. Treatment for CVID mainly consists of immunoglobulin replacement therapy, administered intravenously or subcutaneously, which must be given for life.