# Predictors of trajectories of child neurodevelopment in the first 2 years of life in LMICs: A systematic review and meta-analysis protocol

## TL;DR

This study aims to identify factors affecting early childhood brain development in low-and-middle-income countries to help design better interventions.

## Contribution

A systematic review and meta-analysis protocol to identify predictors of early child neurodevelopment in LMICs.

## Key findings

- The study will identify predictors of child neurodevelopment in the first two years of life in LMICs.
- Findings may guide interventions to optimize neurodevelopmental outcomes in early childhood.
- The protocol uses PRISMA-P guidelines and GRADE for bias assessment.

## Abstract

In low-and-middle-income countries (LMICs), children are exposed to multiple risks that may compromise their neurodevelopment, especially during the early years. Early childhood developmental trajectories are crucial, especially in such at-risk populations as they help predict future neurocognitive potential. In LMICs where numerous factors shape child neurodevelopment, describing neurodevelopment trajectories and understanding the predictors that shape them is imperative for early intervention. The systematic review and meta-analysis will determine the predictors of trajectories of child neurodevelopment during the first 2 years of life in LMICs.

The Preferred Reporting Items for Systematic Review and meta-analysis protocols (PRISMA-P) guidelines will be followed while performing this review. PubMed, Psych INFO, EMBASE, and Google Scholar databases and reference lists of relevant articles will be searched for articles. Selected publications will be uploaded to Endnote to remove duplicates and reviewed by title, abstract, and full text to identify those meeting the eligibility criteria. Longitudinal studies on child neurodevelopment and associated predictors among children aged ≤ 24 months in LMICs will be included. Screening, data extraction, and critical appraisal will be done by two autonomous reviewers. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) will evaluate the risk of bias and funnel plot asymmetry, publication bias. The I2 statistics will be used to test for heterogeneity in the selected studies and STATA-18 and EPPI-reviewer software for statistical analysis. A random-effects meta-analysis will be undertaken.

The protocol describes a systematic review and meta-analysis aimed at identifying factors influencing neurodevelopment trajectories during the first 2 years of life in LMICs. The review findings may provide a comprehensive understanding of the factors that influence child neurodevelopment, particularly in the first 2 years of life in LMICs, help identify critical windows of opportunity for intervention, and potentially guide the design of age and contextually appropriate interventions for optimizing neurodevelopmental outcomes, especially in this context.

International Prospective Register of Systematic Reviews (PROSPERO), CRD42023421753.