# A peek into the pipeline: Expert views on emerging therapies **Authors:** Ilse Dewachter, Günter U. Höglinger, Daniel J. Drucker, Christine E. Brown, Roland Martin, Anne Bernadette Chang, Sanjay Haresh Chotirmall, Xiaolong Qi, Pamela Shaw PMC · DOI: 10.1016/j.xcrm.2025.102083 · Cell Reports Medicine · 2025-04-15 ## Full-text entities - **Genes:** mucin [NCBI Gene 100508689], TREM2 (triggering receptor expressed on myeloid cells 2) [NCBI Gene 54209] {aka AD17, PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, ELANE (elastase, neutrophil expressed) [NCBI Gene 1991] {aka ELA2, GE, HLE, HNE, NE, PMN-E}, PRTN3 (proteinase 3) [NCBI Gene 5657] {aka ACPA, AGP7, C-ANCA, CANCA, MBN, MBT}, GLP1R (glucagon like peptide 1 receptor) [NCBI Gene 2740] {aka GLP-1, GLP-1-R, GLP-1R}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, HSF1 (heat shock transcription factor 1) [NCBI Gene 3297] {aka HSTF1}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, FUS (FUS RNA binding protein) [NCBI Gene 2521] {aka ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS}, IL13RA2 (interleukin 13 receptor subunit alpha 2) [NCBI Gene 3598] {aka CD213A2, CT19, IL-13R, IL13BP}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, CTSC (cathepsin C) [NCBI Gene 1075] {aka CPPI, DPP-I, DPP1, DPPI, HMS, JP}, MUC5AC (mucin 5AC, oligomeric mucus/gel-forming) [NCBI Gene 4586] {aka MUC5, TBM, leB, mucin}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, IFNA1 (interferon alpha 1) [NCBI Gene 3439] {aka IFL, IFN, IFN-ALPHA, IFN-alphaD, IFNA13, IFNA@}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, CTSG (cathepsin G) [NCBI Gene 1511] {aka CATG, CG}, CD276 (CD276 molecule) [NCBI Gene 80381] {aka 4Ig-B7-H3, B7-H3, B7H3, B7RP-2}, APOE (apolipoprotein E) [NCBI Gene 348] {aka AD2, APO-E, ApoE4, LDLCQ5, LPG}, GCG (glucagon) [NCBI Gene 2641] {aka GLP-1, GLP1, GLP2, GRPP}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, ATXN2 (ataxin 2) [NCBI Gene 6311] {aka ATX2, SCA2, TNRC13}, C9orf72 (C9orf72-SMCR8 complex subunit) [NCBI Gene 203228] {aka ALSFTD, DENND9, DENNL72, FTDALS, FTDALS1}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19} - **Diseases:** stroke (MESH:D020521), brain tumors (MESH:D001932), primary biliary cholangitis (MESH:D008105), weight loss (MESH:D015431), inflammation (MESH:D007249), cirrhosis (MESH:D005355), myocardial infarction (MESH:D009203), hepatic decompensation (MESH:D006333), AIDs (MESH:D001327), Bronchiectasis (MESH:D001987), malignant (MESH:D009369), pulmonary exacerbations (MESH:D018450), MND (MESH:D016472), amyotrophic lateral sclerosis (MESH:D000690), glioblastoma (MESH:D005909), amyloid (MESH:C000718787), Neurodegenerative Diseases (MESH:D019636), AD (MESH:D000544), stiffness (MESH:C566112), overweight (MESH:D050177), cardiovascular death (MESH:D002318), MS (MESH:D009103), T1D (MESH:D003922), tauopathy (MESH:D024801), T2D (MESH:D003924), CSPH (MESH:D006975), chronic kidney disease (MESH:D051436), obesity (MESH:D009765), Liver Disease (MESH:D008107) - **Chemicals:** resmetirom (MESH:C588408), brensocatib (MESH:C000619932), carvedilol (MESH:D000077261), M102 (MESH:C000593473), glucose (MESH:D005947), lecanemab (MESH:C000612089), oligonucleotide (MESH:D009841), daclizumab (MESH:D000077561), tofersen (MESH:C000709090), ASO (MESH:D016376), macrolides (MESH:D018942), BIIB080 (-) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12047454/full.md ## Figures 7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12047454/full.md --- Source: https://tomesphere.com/paper/PMC12047454