# Combination Therapy With Voclosporin and Anifrolumab in Two Patients With Lupus Nephritis and Discoid Lupus Erythematosus

## TL;DR

Two patients with lupus were successfully treated with a combination of Voclosporin and Anifrolumab, achieving remission without steroids.

## Contribution

Demonstrates successful treatment of lupus nephritis and discoid lupus with a steroid-free combination therapy.

## Key findings

- Patients achieved remission using Voclosporin and Anifrolumab without oral steroids.
- Treatment was safe and effective in managing lupus disease activity.
- Combination therapy minimized drug toxicity and prevented damage accrual.

## Abstract

Current therapeutic options in systemic lupus erythematosus (SLE) vary in effectiveness, and remission may not be achievable in many patients. Unfortunately, although many patients achieve an initial response with conventional immunosuppressant regimens, relapse is common, and current therapies are associated with damaging adverse effects and the risk of infection. Therefore, it is critical to identify safe targets for lupus disease activity, minimizing drug toxicity and preventing damage accrual. We present two cases with disease features of discoid lupus erythematosus (DLE) and lupus nephritis (LN), who were treated safely and successfully with Voclosporin and Anifrolumab, resulting in disease remission without the use of oral steroids.