# Incidence Status and Factors Associated With Tyrosine Kinase Inhibitor‐Induced Hypertension in Patients With Renal Cell Carcinoma

## TL;DR

This study examines how often tyrosine kinase inhibitors cause hypertension in kidney cancer patients and explores factors influencing this side effect.

## Contribution

The study provides new insights into the risk factors and management of hypertension caused by tyrosine kinase inhibitors in renal cell carcinoma patients.

## Key findings

- 36.4% of patients experienced TKI-induced hypertension.
- Calcium channel blockers were the most prescribed antihypertensive agents.
- Pre-existing hypertension was a risk factor, but PPIs did not reduce the risk.

## Abstract

Although hypertension is a common side effect of tyrosine kinase inhibitor (TKI) treatment for renal cell carcinoma (RCC), there is limited evidence regarding its occurrence and related risk factors. Preliminary studies suggest that proton pump inhibitors (PPIs) may mitigate the risk of TKI‐induced hypertension; however, their clinical effectiveness remains unclear.

In this study, we examined the prevalence of TKI‐induced hypertension and the patterns of antihypertensive prescriptions among patients with RCC in Japan. Additionally, we investigated factors associated with TKI‐induced hypertension to assess the potential impact of PPIs.

Data from patients diagnosed with RCC who were prescribed TKIs between April 2008 and July 2021 were retrospectively gathered from a Japanese administrative database. TKI‐induced hypertension was detected following the diagnosis of hypertension and subsequently the prescription of an antihypertensive agent during TKI therapy. The prescription details for antihypertensive agents were organized in a tabular format. Cox proportional hazards regression analysis was conducted to examine factors contributing to TKI‐induced hypertension. Among the 225 patients analyzed, 36.4% experienced hypertension, and calcium channel blockers were the most prescribed antihypertensive agents. Pre‐existing hypertension was identified as a risk factor for TKI‐induced hypertension, while the concurrent use of PPIs did not show a tendency to reduce the risk of TKI‐induced hypertension.

These findings indicate the importance of blood pressure management in patients with elevated baseline blood pressure.