# Triple Valve Endocarditis and Multiorgan Failure: A Clinical Conundrum

**Authors:** Amey Joshi, Sarah P Alizadeh, Harith Ghnaima, Zan Siddiqi, Selwan Edward

PMC · DOI: 10.7759/cureus.81603 · Cureus · 2025-04-02

## TL;DR

This paper presents a rare case of triple valve infective endocarditis in a young man with multiple comorbidities and highlights the challenges in treatment.

## Contribution

The novelty lies in describing a rare clinical case with multiple high-risk factors and limited treatment options.

## Key findings

- Triple valve infective endocarditis is rare and associated with high mortality and limited surgical options.
- The case involved a young man with liver cirrhosis and atrial fibrillation, complicating treatment.
- The patient developed endocarditis in all three heart valves, emphasizing the need for better treatment strategies.

## Abstract

Triple valve infective endocarditis is a rare clinical diagnosis with limited evidence on treatment strategies. Complications, including congestive heart failure, renal failure, and persistent bacteremia, predispose to increased mortality risk and limit surgical options. Due to its rarity, little is known about its prognosis and best treatment strategies. We present a case of a young man with multiple comorbidities, including liver cirrhosis and paroxysmal atrial fibrillation, who was diagnosed with right-sided infective endocarditis. Due to the patient’s complex clinical course, his admission was complicated with infective endocarditis of the tricuspid valve, mitral valve, and aortic valve. Alongside its rarity, this case highlights the limited interventions at our disposal in treating triple valve endocarditis with multiple high-risk factors.

## Linked entities

- **Diseases:** paroxysmal atrial fibrillation (MONDO:1030011), infective endocarditis (MONDO:0000565)

## Full-text entities

- **Diseases:** Multiorgan Failure (MESH:D051437), congestive heart failure (MESH:D006333), bacteremia (MESH:D016470), Triple valve infective endocarditis (MESH:D004696), liver cirrhosis (MESH:D008103), atrial fibrillation (MESH:D001281), Triple Valve Endocarditis (MESH:C536008)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12046873/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12046873/full.md

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Source: https://tomesphere.com/paper/PMC12046873