Pediatric Pituitary Adenomas and Cysts: A 46-Year Population-Based Analysis

TL;DR

This study analyzes 46 years of pediatric pituitary adenoma and cyst cases to understand their incidence, characteristics, and progression.

Contribution

A population-based analysis of pediatric pituitary lesions over 46 years, revealing their rarity and stability.

Findings

Pediatric pituitary adenomas and cysts had an incidence of 2.29 cases per 100,000 person-years.

Most lesions were small, nonfunctioning, and stable over long-term follow-up.

Lesion size or headaches were not linked to disease progression.

Abstract

Pituitary adenomas and cysts are rare in pediatric patients and improved understanding can guide management recommendations.

To report incidence, presentation, management, and outcomes in a pediatric population-based cohort with pituitary adenomas and cysts, and to explore the relationship between these lesions and brain magnetic resonance imaging (MRI) rates, as well as lesion size and headaches with disease progression.

In this retrospective cohort study of pediatric patients (≤18 years) with incident pituitary adenomas and cysts in Olmsted County, MN, from 1976 to 2021, 234 unique patients were identified using diagnostic codes through the Rochester Epidemiology Project, with 37 confirmed cases of pituitary adenoma or cyst included. Incidence rates were calculated using census data. Descriptive statistics were used for extracted clinical data.

Incidence of pediatric adenomas and cysts was 2.29 cases per 100 000 person-years. Of the 37 cases, 68% were nonfunctioning adenomas or cysts, 27% were prolactinomas, and there was 1 each of growth hormone (GH)– and thyrotropin (TSH)-secreting adenomas. Median lesion diameter was 5.5 mm (IQR, 4.0-8.0). Median follow-up was 7.4 years (IQR, 4.5-15.4). Four patients had disease progression which stabilized with second-line therapy. Brain MRI rates did not correlate with lesion incidence. No clinically meaningful relationship was found between lesion size or headache and disease progression.

Pituitary adenomas and cysts are rare in pediatric patients. Most are small, nonfunctioning, and stable on long-term follow-up. Larger studies on small nonfunctioning pituitary lesions are needed to enhance understanding of their natural history and develop long-term management recommendations.

Figures