# Molecular Factors Involved in the Pathogenesis of Pyometra in Domestic Cats (Felis catus)

## TL;DR

This paper reviews molecular factors involved in cat pyometra, a serious uterine infection, to improve diagnosis and treatment.

## Contribution

The study provides a comprehensive review of molecular factors in feline pyometra, which is less understood than in dogs.

## Key findings

- Pyometra in cats is linked to hormonal, redox, immunological, and growth factors.
- Understanding these factors could lead to better diagnosis and treatment strategies.
- The condition often occurs during diestrus and can be caused by improper hormonal medication.

## Abstract

This article reviews the molecular factors causing pyometra in domestic cats, a serious uterine infection. While well-studied in dogs, pyometra in cats is less understood. The focus is on hormonal, redox, immunological, and growth factors, aiming to improve the diagnosis and treatment of the disease.

Pyometra is a major reproductive disorder affecting female cats. Characterized by the accumulation of purulent exudate in the uterus, it can lead to severe and potentially fatal complications. This pathology primarily occurs in adult cats during diestrus, but can also affect younger felines, often due to inappropriate administration of hormonal medications. While the etiopathogenesis of pyometra is better understood in bitches, few studies have addressed the molecular factors involved in feline pyometra. Therefore, this review aims to provide an up-to-date and comprehensive discussion of pyometra in cats, focusing on the regulation of molecular factors described in this species, including hormonal, redox, immunological, and growth factors. Understanding the regulation of these factors in pyometra is crucial for elucidating its pathogenesis in domestic cats and for improving diagnosis and identifying novel therapeutic approaches.