The Impact of Clotting Disorders on Gastrointestinal Health: A Case Report of Bowel Ischemia Due to Thrombus Formation in Antiphospholipid Syndrome and Factor V Leiden

TL;DR

A 49-year-old woman with clotting disorders developed bowel ischemia due to a thrombus, emphasizing the need for early diagnosis in hypercoagulable conditions.

Contribution

This case report highlights the rare but severe gastrointestinal complication of antiphospholipid syndrome and Factor V Leiden.

Findings

The patient presented with nonspecific symptoms but was diagnosed with mesenteric venous thrombosis.

Early diagnosis and intervention are critical to prevent life-threatening complications in hypercoagulable patients.

Thrombosis in the superior mesenteric vein can lead to bowel ischemia in individuals with clotting disorders.

Abstract

Antiphospholipid syndrome and Factor V Leiden are well-recognized hypercoagulable disorders associated with an increased risk of thrombosis in major vascular structures. One of the most severe complications is thrombosis of the superior mesenteric vein and its branches, which can lead to impaired blood flow and bowel ischemia. This report presents the case of a 49-year-old woman with underlying hypercoagulable conditions who initially presented with nonspecific gastrointestinal symptoms and unremarkable laboratory findings, ultimately diagnosed with mesenteric venous thrombosis. The case highlights the importance of maintaining a high index of clinical suspicion, facilitating early diagnosis, and ensuring timely intervention to prevent life-threatening complications.

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