Low serum free IL-18 is a novel potential marker for predicting infectious events in patients at dialysis initiation

TL;DR

Low levels of free IL-18 in dialysis patients may predict a higher risk of severe infections.

Contribution

Identifies low serum free IL-18 as a novel potential biomarker for predicting infectious events in dialysis patients.

Findings

Low free IL-18 (<6.0 pmol/l) was independently associated with infectious events.

Total IL-18 and IL-18BP showed no association with infectious events.

Cumulative incidence of infections was significantly higher in the low free IL-18 group.

Abstract

Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] concentration as a prognostic factor for hemodialysis patients' infection risk.

The Ibaraki Dialysis Initiation Cohort (iDIC) study is a multicenter prospective cohort investigation of patients undergoing a new initiation of dialysis in a local region of Japan. We performed a survival analysis of several events requiring hospitalization and compared the Kaplan–Meier curves of the “low” and “high” serum free IL-18 concentration groups. To adjust for confounding factors, we also performed a Cox proportional hazards analysis.

We analyzed the serum free IL-18 concentration of samples from 295 patients randomly selected from the blood sample bank of the iDIC study. The mean free IL-18 concentration was 8.7 ± 5.3 pmol/l. The cumulative incidence of infectious events was significantly higher in the low free IL-18 group (<6.0 pmol/l, log-rank test P < .01). The Cox proportional hazards analysis revealed that low serum free IL-18 (<6.0 pmol/l) was an independent factor associated with the development of infectious events. Total IL-18 and IL-18BP (binding protein) showed no association with infectious events.

A low serum free IL-18 concentration in the dialysis initiation period is a potential marker for predicting the development of severe infection in these patients.

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