# Self-Reported SARS-CoV-2 Infections among National Blood Donor Cohort, United States, 2020–2022

## TL;DR

Blood donor data shows patterns of first and repeat SARS-CoV-2 infections in the U.S. from 2020–2022, aligning with public health reports and highlighting reinfection trends.

## Contribution

This study uses blood donor data to track SARS-CoV-2 reinfections, offering a novel approach to infectious disease surveillance.

## Key findings

- Self-reported first and repeat SARS-CoV-2 infections in blood donors matched public health case counts.
- Reinfection incidence among blood donors peaked in 2022.
- Blood donor data can complement traditional surveillance systems for emerging infectious diseases.

## Abstract

SARS-CoV-2 case surveillance in the United States did not distinguish first infections from reinfections. In a large blood donor cohort, self-reported first infections and reinfections during 2020–2022 mirrored public health case count surveillance, and reinfection incidence peaked in 2022. Blood donor data could aid in SARS-CoV-2 and emerging infectious disease surveillance.